It is too early to translate the tubal hypothesis of ovarian cancer into clinical practice by delaying oopherectomy, an Australian oncologist warns.
According to the hypothesis, cancer arose from a precursor lesion in the fallopian tube, which progressed to an invasive, high grade, type II tumour that ultimately involved the ovary itself, Dr Gillian Mitchell from the Peter MacCallum Cancer Centre in Melbourne and international colleagues explained.
This notion was attractive because it lent itself to a staged approach to surgical prevention – delaying bilateral oopherectomy.
However the authors stressed that evidence was still circumstantial, despite some oncologists already discussing the staged approach with patients.
“There is a real concern that research is being translated prematurely into routine clinical practice without robust evidence,”...
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