UVA1 may be more carcinogenic than previously thought, with researchers finding it induces molecular lesions, particular at increased skin depths.
The findings have serious implications for sun-safe recommendations, an Australian expert says, with the risk factors for UVA – which is 20 times more abundant than UVB – being considerably different.
Reporting in the Journal of Investigative Dermatology, the researchers compared the DNA-damaging effects of UVA1 and UVB in the skin of 12 volunteers.
UVA1 induced one type of molecular lesion – thymine dimmers (TTs) – which increased at increased epidermal depth.
The researchers also replicated earlier findings that UVB induced both TTs and pyrimidone photoproducts (604PPs), which decrease at deeper epidermal levels.
Professor Michael Kimlin, director of the NHMRC...
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